Targeting JAK2 in myeoloproliferative neoplasms (MPN)

Myeloproliferative Neoplasms (MPNs) are blood cancers that occur when the body makes too many white or red blood cells, or platelets. This overproduction of blood cells in the bone marrow can create problems for blood flow and lead to various symptoms. MPNs were called Myeloproliferative Diseases until 2008 when the World Health Organization re-classified them as cancers and named them Myeloproliferative Neoplasms.

There are three main types of MPNs:

  • Primary Myelofibrosis (PMF)
  • Polycythemia vera (PV)
  • Essential thrombocythemia (ET)
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